Factors related to long COVID in the adult population of Brazil
DOI:
https://doi.org/10.26694/reufpi.v12i1.3811Keywords:
COVID-19, COVID longa, Sinais e sintomas, Fatores de risco, BrasilAbstract
Objetivo: Analisar os fatores relacionados à COVID longa na população adulta do Brasil. Métodos: Estudo transversal analítico, do tipo web-survey, com abordagem quantitativa. A amostragem foi não probabilística, do tipo intencional, e incluiu 228 adultos brasileiros que testaram positivo para COVID-19. A coleta de dados ocorreu por meio de questionário online. Para verificar a associação entre variáveis qualitativas, utilizou-se o Teste Qui-quadrado ou Teste Exato de Fisher e, nas quantitativas, aplicou-se o Teste de Mann-Whitney com significância de 0,05. Resultados: Constatou-se que houve associação de variáveis sociodemográficas com a COVID longa. Observa-se maior média de idade entre aqueles em que persistiram os sintomas (p=0,041). A renda familiar daqueles com sintomas persistentes era inferior à dos indivíduos sem persistência (p=0,005). A prática de atividade física esteve associada a não persistência dos sintomas (p=0,024). A hipertensão arterial foi a comorbidade mais prevalente naqueles com sintomas persistentes (5,9%). No quadro clínico de COVID-19 associado à persistência dos sintomas, identificam-se calafrios (p-valor=0,009), cefaleia (p-valor=0,0027), tosse (p-valor=0,000), anosmia (p-valor=0,048), ageusia (p-valor=0,013), dispneia (p-valor=0,000) e diarreia (p-valor=0,018). O sintoma de COVID longa mais prevalente foi fadiga (62,89%). Conclusão: Idade e renda estiveram associadas à COVID longa. Praticar atividade física esteve associado a não persistência de sintomas.
References
Brito SB, Braga IO, Cunha CC, Palácio MA, Takenami I. COVID-19 pandemic: the biggest challenge for the 21st century. Vigil. sanit. debate. 2020; 8(2):54-63. doi: https://doi.org/10.22239/2317-269x.01531
Organização Mundial da Saúde. OMS afirma que COVID-19 é agora caracterizada como pandemia [Internet]. Genebra: OMS, 2020 [citado 2022 maio 09]. Available from:https://www.paho.org/pt/news/11-3-2020-who-characterizes-covid-19-pandemic
Mahase E. Covid-19: What do we know about "long covid"? BMJ. 2020; 370:m2815. doi: https://doi.org/10.1136/bmj.m2815
Dani M, Dirksen A, Taraborrelli P, Torocastro M, Panagopoulos D, Sutton R, et al. Autonomic dysfunction in 'long COVID': rationale, physiology and management strategies. Clin Med (Lond). 2021; 21(1):e63-e67. doi: https://doi.org/10.7861/clinmed.2020-0896
Garg P, Arora U, Kumar A, Wig N. The "post-COVID" syndrome: How deep is the damage? J Med Virol. 2021; 93(2):673-4. doi: https://doi.org/10.1002/jmv.26465
Davis HE, Assaf GS, McCorkell L, Wei H, Low RJ, Re'em Y, et al. Characterizing long COVID in an international cohort: 7 months of symptoms and their impact. EClinicalMedicine. 2021; 38:101019. doi: https://doi.org/10.1016/j.eclinm.2021.101019
Moreno-Pérez O, Merino E, Leon-Ramirez JM, Andres M, Ramos JM, Arenas-Jiménez J, et al. Post-acute COVID-19 syndrome. Incidence and risk factors: A Mediterranean cohort study. J Infect. 2021;82(3):378-83. doi: https://doi.org/10.1016/j.jinf.2021.01.004
GemelliAgainst COVID-19 Post-Acute Care Study Group. Post-COVID-19 global health strategies: the need for an interdisciplinary approach. Aging Clin Exp Res. 2020; 32(8):1613-20. doi: https://doi.org/10.1007/s40520-020-01616-x
Vandenbroucke JP, von Elm E, Altman DG, Gøtzsche PC, Mulrow CD, Pocock SJ, et al. Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): explanation and elaboration. Epidemiology. 2007;18(6):805-35. doi: https://doi.org/10.1097/EDE.0b013e3181577511
Asadi-Pooya AA, Akbari A, Emami A, Lotfi M, Rostamihosseinkhani M, Nemati H, et al. Risk Factors Associated with Long COVID Syndrome: A Retrospective Study. Iran J Med Sci. 2021;46(6):428-36. doi: https://doi.org/10.30476/ijms.2021.92080.2326
Lombardo MD, Foppiani A, Peretti GM, Mangiavini L, Battezzati A, Bertoli S, et al. Long-Term Coronavirus Disease 2019 Complications in Inpatients and Outpatients: A One-Year Follow-up Cohort Study. Open Forum Infect Dis. 2021;8(8):ofab384. doi: https://doi.org/10.1093/ofid/ofab384
Glynne P, Tahmasebi N, Gant V, Gupta R. Long COVID following mild SARS-CoV-2 infection: characteristic T cell alterations and response to antihistamines. J Investig Med. 2022; 70(1):61–7. doi: https://doi.org/10.1136/jim-2021-002051
Mahmud R, Rahman MM, Rassel MA, Monayem FB, Sayeed SKJB, Islam MS, et al. Post-COVID-19 syndrome among symptomatic COVID-19 patients: A prospective cohort study in a tertiary care center of Bangladesh. PLoS One. 2021; 16(4):e0249644. doi: https://doi.org/10.1371/journal.pone.0249644
Dennis A, Wamil M, Alberts J, Oben J, Cuthbertson DJ, Wootton D, et al. Multiorgan impairment in low-risk individuals with post-COVID-19 syndrome: a prospective, community-based study. BMJ Open. 2021;11(3):e048391. doi: http://doi.org/10.1136/bmjopen-2020-048391
Pelà G, Goldoni M, Solinas E, Cavalli C, Tagliaferri S, Ranzieri S, et al. Sex-Related Differences in Long-COVID-19 Syndrome. J Womens Health (Larchmt). 2022;31(5):620-30. doi: https://doi.org/10.1089/jwh.2021.0411
Barbalho EV, Gomes ML, Pereira TC, Pedrosa EC, Linard CF, Pinto FJ. Sociodemographic indicators in the pandemic of covid-19 through space distribution in brazil: Integrative review. Res Soc Dev. 2021; 10(6):e34110615507. doi: https://doi.org/10.33448/rsd-v10i6.15507
Mattei L, Heinen VL. Balance of the impacts of the COVID-19 crisis on the Brazilian labor market in 2020. Rev. Katál. 2022; 25(1):43–61. doi: https://doi.org/10.1590/1982-0259.2022.e82492
Aguiar BF, Sarquis LM, Miranda FM. Sequelae of Covid-19: a reflection on the impacts on the health of the worker. Res Soc Dev. 2021;10(14):e40101421886. doi: http://dx.doi.org/10.33448/rsd-v10i14.21886
Peghin M, Palese A, Venturini M, De Martino M, Gerussi V, Graziano E, et al. Post-COVID-19 symptoms 6 months after acute infection among hospitalized and non-hospitalized patients. Clin Microbiol Infect. 2021; 27(10):1507-13. doi: https://doi.org/10.1016/j.cmi.2021.05.033
Cruz NA, Andriani MT, Pimenta TS, Fernandes AR, Pereira RC. Repercussion of Covid-19 infection in the elderly: an integrative review. Res Soc Dev. 2022; 11(2):e0811223910. doi: https://doi.org/10.33448/rsd-v11i2.23910
Silveira MP, Fagundes KK, Bizuti MR, Starck E, Rossi RC, Silva DT. Physical exercise as a tool to help the immune system against COVID-19: an integrative review of the current literature. Clin Exp Med. 2021;21(1):15-28. doi: https://doi.org/10.1007/s10238-020-00650-3
Bartlett DB, Willis LH, Slentz CA, Hoselton A, Kelly L, Huebner JL, et al. Ten weeks of high-intensity interval walk training is associated with reduced disease activity and improved innate immune function in older adults with rheumatoid arthritis: a pilot study. Arthritis Res Ther. 2018;20(127):1-15. doi: https://doi.org/10.1186/s13075-018-1624-x
Dieli-Conwright CM, Courneya KS, Demark-Wahnefried W, Sami N, Lee K, Sweeney FC, et al. Aerobic and resistance exercise improves physical fitness, bone health, and quality of life in overweight and obese breast cancer survivors: a randomized controlled trial. Breast Cancer Res. 2018;20(124):1-10. doi: https://doi.org/10.1186/s13058-018-1051-6
Mohamed AA, Alawna M. The effect of aerobic exercise on immune biomarkers and symptoms severity and progression in patients with COVID-19: A randomized control trial. J Bodyw Mov Ther. 2021;425-32. doi: https://doi.org/10.1016/j.jbmt.2021.07.012
Li S, Hua X. Modifiable lifestyle factors and severe COVID-19 risk: a Mendelian randomisation study. BMC Med Genomics. 2021;14(38). doi: https://doi.org/10.1186/s12920-021-00887-1
Tabacof L, Tosto-Mancuso J, Wood J, Cortes M, Kontorovich A, McCarthy D, et al. Post-acute COVID-19 Syndrome Negatively Impacts Physical Function, Cognitive Function, Health-Related Quality of Life, and Participation. Am J Phys Med Rehabil. 2022;101(1):48-52. doi: https://doi.org/10.1097/PHM.0000000000001910
Carvalho-Schneider C, Laurent E, Lemaignen A, Beaufils E, Bourbao-Tournois C, Laribi S, et al. Follow-up of adults with noncritical COVID-19 two months after symptom onset. Clin Microbiol Infect. 2021; 27(2):258-63. doi: https://doi.org/10.1016/j.cmi.2020.09.052
Bellan M, Soddu D, Balbo PE, Baricich A, Zeppegno P, Avanzi GC, et al. Respiratory and Psychophysical Sequelae Among Patients With COVID-19 Four Months After Hospital Discharge. JAMA Netw Open. 2021; 4(1):e2036142. doi: https://doi.org/10.1001/jamanetworkopen.2020.36142
Carfì A, Bernabei R, Landi F; GemelliAgainst COVID-19 Post-Acute Care Study Group. Persistent Symptoms in Patients After Acute COVID-19. JAMA. 2020; 324(6):603-605. doi: https://doi.org/10.1001/jama.2020.12603
De Lorenzo R, Conte C, Lanzani C, Benedetti F, Roveri L, Mazza MG, et al. Residual clinical damage after COVID-19: A retrospective and prospective observational cohort study. PLoS One. 2020; 15(10):e0239570. doi: https://doi.org/10.1371/journal.pone.0239570
Huang C, Huang L, Wang Y, Li X, Ren L, Gu X, et al. 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. Lancet. 2021;397(10270):220-32. doi: https://doi.org/10.1016/S0140-6736(20)32656-8
Naik S, Haldar SN, Soneja M, Mundadan NG, Garg P, Mittal A et al. Post COVID-19 sequelae: A prospective observational study from Northern India. Drug Discov Ther. 2021 Nov 21;15(5):254-60. doi: https://doi.org/10.5582/ddt.2021.01093
Zulu JE, Banda D, Hines JZ, Luchembe M, Sivile S, Siwingwa M, et al. Two-month follow-up of persons with SARS-CoV-2 infection-Zambia, September 2020: a cohort study. Pan Afr Med J. 2022; 41(26). doi: https://doi.org/10.11604/pamj.2022.41.26.30721
Arnold DT, Hamilton FW, Milne A, Morley AJ, Viner J, Attwood M, et al. Patient outcomes after hospitalisation with COVID-19 and implications for follow-up: results from a prospective UK cohort. Thorax. 2021; 76(4):399-401. doi: https://doi.org/10.1136/thoraxjnl-2020-216086
Cheng D, Calderwood C, Skyllberg E, Ainley A. Clinical characteristics and outcomes of adult patients admitted with COVID-19 in East London: a retrospective cohort analysis. BMJ Open Respir Res. 2021; 8(1):e000813. doi: https://doi.org/10.1136/bmjresp-2020-000813
Poyraz BÇ, Poyraz CA, Olgun Y, Gürel Ö, Alkan S, Özdemir YE, et al. Psychiatric morbidity and protracted symptoms after COVID-19. Psychiatry Res. 2021; 295:113604. doi: https://doi.org/10.1016/j.psychres.2020.113604
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Rev Enferm UFPI
This work is licensed under a Creative Commons Attribution 4.0 International License.
Autores mantém os direitos autorais e concedem à REUFPI o direito de primeira publicação, com o trabalho licenciado sob a Licença Creative Commons Attibution BY 4.0 que permite o compartilhamento do trabalho com reconhecimento da autoria e publicação inicial nesta revista.