Blood culture findings as tools for clinical management and patient safety
DOI:
https://doi.org/10.26694/repis.v8i1.2812Keywords:
Blood Culture, Microbiology, Health Status Indicators, Patient Safety, AntimicrobialsAbstract
Introduction: Healthcare-associated Infections (HAI) have a significant impact on public health, and the use of indicators is a common practice for assessing and improving healthcare services. Aim: This study aimed to describe the utilization of blood culture results to develop indicators for hospital management and evaluate antimicrobial resistance. Outlining: This cross-sectional study was conducted at a teaching hospital. Blood cultures were performed during two periods: pre-implementation of antimicrobial sales restrictions in Brazil (05/2010-10/2010 - first period) and post-implementation (02/2011-07/2011 - second period). Computerized system reports were used to develop indicators, including infection incidence rates and antimicrobial resistance. Results: A higher infection rate (1.97/100 person-days) and a lower resistance rate (0.62/100 person-days) were observed in the second period, with the microorganism Staphylococcus sp. being more frequently identified in both periods. Implications: This study demonstrates the use of indicators to evaluate governmental actions related to HAIs, which can contribute to patient safety and healthcare management.
References
Souza ES, Belei RA, Carrilho CMDdM, Tiemi M, Sueli Fumie Y-O, Galdino A, et al. Mortalidade e riscos associados a infecção relacionada à assistência à saúde. Texto contexto - enferm [Internet]. 2015 [cited 2022 Fev 10];24(1):220-8. Available from: https://doi.org/10.1590/0104 07072015002940013
Center for Disease Control and Prevention. Identifying Healthcare-associated Infections (HAI) for NHSN surveillance. Atlanta: CDC; 2018.
Rulka EL, Lima M, Neves EB. Perfil das publicações científicas sobre a infecção hospitalar. J Health Sci Inst [Internet]. 2012 [cited 2022 Fev 10]; 30(2):161-9. Available from: https://repositorio.unip.br/wp-content/uploads/2020/12/V30_n2_2012_p161-165.pdf
Agência Nacional de Vigilância Sanitária. Programa nacional de prevenção e controle de infecções relacionadas à assistência à saúde (2016-2020). Brasília, DF: ANVISA, 2016. Available from: https://www.saude.go.gov.br/images/imagens_migradas/upload/arquivos/2017 02/pnpciras-2016-2020.pdf
World Health Organization. Antimicrobial resistance: global report on surveillance. WHO Library Cataloguing-in-Publication Data; 2014. Available from: https://apps.who.int/iris/handle/10665/112642
Roca I, Akova M, Baquero F, Carlet J, Cavaleri M, Coenen S, et al. The global threat of antimicrobial resistance: science for intervention. New Microbes New Infect [Internet]. 2015 [cited 2022 Fev 10];6:22-9. Available from: https://doi.org/10.1016/j.nmni.2015.02.007.
SBPC/ML - Sociedade Brasileira de Patologia Clínica / Medicina Laboratorial. Recomendações da Sociedade Brasileira de Patologia Clínica/Medicina Laboratorial (SBPC/ML): boas práticas em microbiologia clínica. Barueri, SP: Manole: Minha Editora; 2015. Available from: https://efivest.com.br/wp-content/uploads/2019/09/microbiologia-clinica.pdf
Knoop ST, Skrede S, Langeland N, Flaatten HK. Epidemiology and impact on all- cause mortality of sepsis in Norwegian hospitals: A national retrospective study. PLoS ONE [Internet]. 2017 [cited 2022 Fev 10];12(11):e0187990. Available from: https://doi.org/10.1371/journal.pone.0187990
Brasil. Ministério da Saúde. RDC nº 44, de 26 de outubro de 2010. Dispõe sobre o controle de medicamentos à base de substâncias classificadas como antimicrobianos, de uso sob prescrição médica, isoladas ou em associação e dá outras providências. Available from: https://bvsms.saude.gov.br/bvs/saudelegis/anvisa/2010/res0044_26_10_2010.html
Costa JMD, Moura CS, Padua CAM, Vegi ASF, Magalhaes SMS, Rodrigues MB, et al. Restrictive measure for the commercialization of antimicrobials in Brazil: results achieved. Rev Saude Publica [Internet]. 2019 [cited 2022 Fev 10];53:68. Available from: https://doi.org/10.11606/s1518-8787.2019053000879
Wacharasint P, Angsusakun C, Jongstapongpun P. Impact of Time to Report Positive Hemoculture on Mortality in Surgical Critically Ill Patients with Septicemia. J Med Assoc Thai [Internet]. 2016 [cited 2022 Fev 10];99 Suppl 6:S219-s25. Available from: https://pubmed.ncbi.nlm.nih.gov/29906383/
Nogueira C, de Mello D, Padoveze MC, Boszczowski I, Levin A, Lacerda R. Characterization of epidemiological surveillance systems for healthcare-associated infections (HAI) in the world and challenges for Brazil. Cad. Saúde Pública [Internet]. 2014 [cited 2022 Fev 10];30(1):11-20. Available from: https://doi.org/10.1590/0102-311X00044113
Lawes T, Lopez-Lozano J-M, Nebot CA, Macartney G, Subbarao-Sharma R, Dare CR, et al. Effects of national antibiotic stewardship and infection control strategies on hospital associated and community- associated meticillin- resistant Staphylococcus aureus infections across a region of Scotland: a non- linear time- series study. The Lancet Infectious Diseases [Internet]. 2015 [cited 2022 Fev 10];15(12):1438-49. Available from: https://doi.org/10.1016/S1473-3099(15)00315-1
Kardas-Sloma L, Boëlle P-Y, Opatowski L, Guillemot D, Temime L. Antibiotic reduction campaigns do not necessarily decrease bacterial resistance: the example of methicillin- resistant Staphylococcus aureus. Antimicrobial agents and chemotherapy [Internet]. 2013 [cited 2022 Fev 10];57(9):4410. Available from: https://doi.org/10.1128/AAC.00711-13
Armin S, Fallah F, Karimi A, Rashidan M, Shirdust M, Azimi L. Genotyping, antimicrobial resistance and virulence factor gene profiles of vancomycin resistance Enterococcus faecalis isolated from blood culture. Microbial Pathogenesis [Internet]. 2017 [cited 2022 Fev 10];109:300-4. Available from: https://doi.org/10.1016/j.micpath.2017.05.039
Mohammed J, Hounmanou YMG, Thomsen LE. Antimicrobial resistance among clinically relevant bacterial isolates in Accra: a retrospective study. BMC research notes [Internet]. 2018 [cited 2022 Fev 10];11(1):254. Available from: https://doi.org/10.1186/s13104-018-3377-7
Obeng-Nkrumah N, Labi A-K, Addison NO, Labi JEM, Awuah-Mensah G. Trends in paediatric and adult bloodstream infections at a Ghanaian referral hospital: a retrospective study. Annals of clinical microbiology and antimicrobials [Internet]. 2016 [cited 2022 Fev 10];15(1):49. Available from: https://doi.org/10.1186/s12941-016-0163-z
Pagano M, Nunes LS, Niada M, Barth AL, Martins AF. Comparative Analysis of Carbapenem-Resistant Acinetobacter baumannii Sequence Types in Southern Brazil: From the First Outbreak (2007-2008) to the Endemic Period (2013-2014). Microb Drug Resist [Internet].2018 [cited 2022 Fev 10];25(4):538-542. Available from: https://doi.org/10.1089/mdr.2018.0262
Nawattanapaiboon K, Prombun P, Santanirand P, Vongsakulyanon A, Srikhirin T, Sutapun B, et al. Hemoculture and Direct Sputum Detection of mecA‐Mediated Methicillin‐Resistant Staphylococcus aureus by Loop‐Mediated Isothermal Amplification in Combination With a Lateral‐Flow Dipstick. J Clin Lab Anal [Internet]. 2016 [cited 2022 Fev 10];30(5):760-7. Available from: https://doi.org/10.1002/jcla.21935
Micenková L, Beňová A, Frankovičová L, Bosák J, Vrba M, Ševčíková A, et al. Human Escherichia coli isolates from hemocultures: Septicemia linked to urogenital tract infections is caused by isolates harboring more virulence genes than bacteraemia linked to other conditions. Int J Med Microbiol [Internet]. 2017 [cited 2022 Fev 10];307(3):182-9. Available from: https://doi.org/10.1016/j.ijmm.2017.02.003
