Stopper fragments in parenteral preparations: a potential problem

Autores

  • Janayna Gomes Pucciarelli Irmandade da Santa Casa de Misericórdia de São Carlos. São Carlos, São Paulo, Brasil
  • Evandro Watanabe Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo, Departamento de Odontologia. Ribeirão Preto, São Paulo, Brasil
  • Simone de Godoy Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo, Departamento de Enfermagem Geral e Especializada. Ribeirão Preto, São Paulo, Brasil
  • Rachel Maciel Monteiro Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo, Departamento de Enfermagem Fundamental. Ribeirão Preto, São Paulo, Brasil
  • Pedro Castania Amadio Domingues Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo, Departamento de Enfermagem Fundamental. Ribeirão Preto, São Paulo, Brasil
  • Leila Maria Marchi-Alves Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo, Departamento de Enfermagem Geral e Especializada. Ribeirão Preto, São Paulo, Brasil

DOI:

https://doi.org/10.26694/repis.v8i.2219

Palavras-chave:

Drug Contamination, Drug Packaging, Rubber, Patient Safety, Medication Error

Resumo

Introduction: The presence of extrinsic particles in injectable solutions is a medication error of usual occurrence that may has important clinical significance. This study aimed to evaluate the presence of stopper fragments in solution derived from bottle-vial after the preparation of drugs using different sorts of needles. Outline: Experimental study, wherein 50 bottles-vials were used, divided into groups. Group 1: stopper perforated with three-bevel tip needle; Group 2: stopper perforated with blunt tip needle; Group 3: without perforation of the stopper. The figure and the size of the particles were determined through optic microscopy. The data were analyzed by means of descriptive statistics and the differences among the groups were analyzed through Fischer’s Exact Test. Results: It was verified the presence of six stopper fragments in the solution derived from five bottles which had the stoppers perforated by three-bevel tip needle (29.4%) and the two fragments in two bottles which had the stoppers perforated with blunt tip needle (11.8%), with significant difference (p=0.044) in the comparison among the groups. The three-bevel tip needle produces larger particles (0.36 mm2) than then blunt tip needle (0.12mm²). Implications: Risk evaluations must enable the limitation, the detection, and the rejection of atypical unities at the time of the drugs’
preparations, preserving patient safety.

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Publicado

2022-03-05

Como Citar

Gomes Pucciarelli, J. ., Watanabe, E. ., de Godoy, S., Maciel Monteiro, R. ., Castania Amadio Domingues, P., & Marchi-Alves, L. M. (2022). Stopper fragments in parenteral preparations: a potential problem. Revista Prevenção De Infecção E Saúde, 8(1). https://doi.org/10.26694/repis.v8i.2219