DETECTION OF FUNGI IN FABRIC TOYS FOR IMMUNOCOMPROMISED CHILDREN

Authors

  • Beatriz Sordi Magalhães Federal University of Mato Grosso do Sul, Integrated Health Institute. Campo Grande, Mato Grosso do Sul, Brazil
  • Tiago Tognolli de Almeida Dom Bosco Catholic University (UCDB), Stricto Sensu Postgraduate Program in Environmental Sciences and Agricultural Sustainability. Campo Grande, Mato Grosso do Sul, Brazil
  • Letícia Maria Acioli Marques Hospital Alemão Oswaldo Cruz. São Paulo, São Paulo, Brazil
  • Liz Eduarda Leite de Castro Federal University of Mato Grosso do Sul, Integrated Health Institute. Campo Grande, Mato Grosso do Sul, Brazil
  • Antonia Railda Roel Dom Bosco Catholic University (UCDB), Stricto Sensu Postgraduate Program in Biotechnology. Campo Grande, Mato Grosso do Sul, Brazil
  • Carina Elisei de Oliveira Dom Bosco Catholic University (UCDB), Stricto Sensu Postgraduate Program in Biotechnology. Campo Grande, Mato Grosso do Sul, Brazil
  • Rodrigo Guimarães dos Santos Almeida Federal University of Mato Grosso do Sul, Integrated Health Institute. Campo Grande, Mato Grosso do Sul, Brazil
  • Maria Angélica Marcheti Federal University of Mato Grosso do Sul, Integrated Health Institute. Campo Grande, Mato Grosso do Sul, Brazil
  • Cristiano Marcelo Espinola Carvalho Dom Bosco Catholic University (UCDB), Stricto Sensu Postgraduate Program in Biotechnology. Campo Grande, Mato Grosso do Sul, Brazil
  • Fernanda Ribeiro Baptista Marques Dom Bosco Catholic University (UCDB), Stricto Sensu Postgraduate Program in Biotechnology. Campo Grande, Mato Grosso do Sul, Brazil

DOI:

https://doi.org/10.26694/repis.v10i1.5701

Keywords:

Oncology Nursing, Invasive Fungal Infections, Games and Toys, Neoplasms, Pediatrics

Abstract

Introduction: Immunosuppression may occur as an adverse reaction to chemotherapy treatment. Thus, neutropenia makes children with cancer susceptible to infectious conditions. In this context, fabric toys bring comfort and coziness, are malleable, and pose no risk of injury, but they can be considered a focus of pathogenic microorganisms. Objective: Identifying fungal microorganisms in fabric toys used by patients undergoing cancer treatment. Method: Samples were collected using swabs soaked in Potato Dextrose (PD) medium directly from the surface of fabric toys, plush toys (B1), and comfort objects (B2), which circulate in hospital and domestic environments of children with oncological diseases. Analysis occurred through molecular identification, conducted by DNA extraction. Results: Six (6) fungal isolates of B1 from the genus Trichoderma and two (2) fungal isolates of B2 from the species Aspergillus niger were obtained. Conclusion: Therefore, the method used allowed identifying fungal microorganisms present in toys at the genus and species level, reinforcing the idea of finding sanitizers or means to promote safe disinfection of plush toys brought from home to prevent their transmission

References

Brasil. Ministério da Saúde. Instituto Nacional do Câncer. Câncer infantojuvenil. Brasília: Ministério da Saúde; 2022. Available from: https://www.gov.br/inca/pt-br/assuntos/cancer/tipos/infantojuvenil

Brasil. Sociedade catarinense de pediatria. Epidemiologia e diagnóstico precoce do câncer infantojuvenil. Brasília: Ministério da Saúde; 2021. Available from: https://www.scp.org.br/wp-content/uploads/2021/09/dc-epidemio-e-diag-precoce-ca-infantojuvenil.pdf

Monteiro C, Gomes CS, Marani LO, Colli LM, Rodrigues R, Pontes LLF. Incidência de covid-19 em pacientes oncológicos em tratamento quimioterápico. Hematol Transfus Cell Ther [Internet]. 2021 [cited 2024 May 24];43(1):534-535. Available from: https://doi.org/10.1016/j.htct.2021.10.922

Silva JHRda, Sachett JdeAG, Resk RL, Teixeira RVM, Duarte GG, Santos CN et al. Prevalência de bactérias patógenas identificadas por swab oral na uti de um centro de controle de oncologia. Braz J Develop [Internet]. 2021 [cited 2024 May 24];7(2):15905–15917. Available from: https://doi.org/10.34117/bjdv7n2-287

Ferreira FL, Bianco ER. A importância do lúdico para crianças hospitalizadas. Glob Acad Nurs [Internet]. 2023 [cited 2024 May 24];4(2):1-12. Available from: https://doi.org/10.5935/2675-5602.20200365

Brasil. Lei nº 8.069, de 13 de julho de 1990. Dispõe sobre o estatuto da criança e do adolescente e dá outras providências. Brasília: Diário Oficial da União; 1990. Available from: https://www.planalto.gov.br/ccivil_03/leis/l8069.htm#:~:text=Disp%C3%B5e%20sobre%20o%20Estatuto%20da,Adolescente%20e%20d%C3%A1%20outras%20provid%C3%AAncias.&text=Art.%201%C2%BA%20Esta%20Lei%20disp%C3%B5e,e%20dezoito%20anos%20de%20idade

Nações Unidas. Declaração dos Direitos da Criança. 20 de novembro de 1959. Available from: https://nacoesunidas.org/carta/

Rodriguez LD. A importância dos jogos e brincadeiras no desenvolvimento infantil. Rev. Científica cognitions [Internet]. 2020 [cited 2024 May 24];1(2):1-12. Available from: https://doi.org/10.38087/2595.8801.28

Aleksejeva V, Dovbenko A, Kroiča J, Skadiņš I. Toys in the Playrooms of Children’s Hospitals: A Potential Source of Nosocomial Bacterial Infections? Children [Internet]. 2021 [cited 2024 May 24];8(10):914. Available from: https://doi.org/10.3390/children8100914

Center for Disease Control and Prevention. Preventing Transmission of Infectious Agents in Healthcare Settings. Atlanta (GA): Centers for Disease Control and Prevention; 2020. Available from: https://www.cdc.gov/infectioncontrol/pdf/guidelines/Isolation-guidelines-H.pdf

Silveira S.S, et al. Ants as bacteria and fungi vectors inside a hospital in South Bahia. Braz J Health Rev [Internet]. 2021 [cited 2024 May 24];4(1):2485-2497. Available from: https://doi.org/10.34119/bjhrv4n1-199

Cordeiro PA dos S, Siqueira GKR, Silva WMTda, Vieira PD de S. Fungos anemófilos associados ao ambiente das enfermarias em unidade hospitalar do Cabo de Santo Agostinho-PE, Brasil. SaBios-Rev Saúd Biol [Internet]. 2021 [cited 2024 May 24];16(1):1–8. Available from: https://doi.org/10.54372/sb.2021.v16.2821

Cardoso LIS, Bagagli E, Mendes RP, Cavalcante RS. Pesquisa de Aspergillus spp em ambiente hospitalar: dados preliminares. Braz J Infect Dis [Internet]. 2022 [cited 2024 May 24];26(S2):102441 Available from: https://doi.org/10.1016/j.bjid.2022.102558

Brasil. Ministério da Saúde. Secretaria de Assistência à Saúde. Orientações gerais para a Central de Esterilização. Brasília: Ministério da Saúde; 2001. Available from: https://bvsms.saude.gov.br/bvs/publicacoes/orientacoes_gerais_central_esterilizacao_p1.pdf

Brasil. Ministério da Saúde. Agência Nacional de Vigilância Sanitária (ANVISA). Resolução da Diretoria Colegiada - RDC nº 15, de 15 de março de 2012. Dispõe sobre requisitos de boas práticas para o processamento de produtos para a saúde e dá outras providências. Brasília: Ministério da Saúde; 2012. Available from: https://bvsms.saude.gov.br/bvs/saudelegis/anvisa/2012/rdc0015_15_03_2012.html

Souza L, Nouér SA, Morales H, Simões B, Solza C, Queiroz-Telles F, Nucci M. Epidemiology of invasive fungal disease in haematologic patients. Mycoses [Internet]. 2021 [cited 2024 May 24]; 64(3):252-256. Available from: https://doi.org/10.1111/myc.13205

Seagle EE, Williams SL, Chiller TM. Recent Trends in the Epidemiology of Fungal Infections. Infec Dis Clinics [Internet]. 2021 [cited 2024 May 24];35(2):237-260. Available from: https://doi.org/10.1016/j.idc.2021.03.001

Skiada A, Pavleas I, Drogari-Apiranthitou M. Epidemiology and Diagnosis of Mucormycosis: An Update. J Fungi [Internet]. 2020 [cited 2024 May 24];6(4):265. Available from: https://doi.org/10.3390/jof6040265

Araújo RKS, Frota VCA, Santana MS, Souza NR. Risco emergente das infecções fúngicas invasivas: revisão da literatura. Rev Ibero-Am Hum, Ciênc Educ [Internet]. 2023 [cited 2024 May 24];9(8):2675–3375. Available from: https://orcid.org/0000-0001-8770-7911

Bastos FF, Perches PV, Marques RS, Canas VB de C, Coimbra CN, Quiñones EM, et al. Contaminação biológica: revisão bibliográfica. Higi@ [Internet]. 2021 [cited 2024 May 24];3(5):1-19. Available from: https://periodicos.unimesvirtual.com.br/index.php/higeia/article/view/1266

Almeida TT, Orlandelli RC, Azevedo JL, Pamphile JA. Molecular characterization of the endophytic fungal community associated with Eichhornia azurea (Kunth) and Eichhornia crassipes (Mart.)(Pontederiaceae) native to the Upper Paraná River floodplain, Brazil. Genet Mol Res [Internet]. 2015 [cited 2024 May 24];14(2):4920-4931. Available from: https://doi.org/10.4238/2015.May.11.25

Tamura K, Stecher G, Kumar S. Mega11: molecular evolutionary genetics analysis version 11. Mol Biol Evol. [Internet]. 2021 [cited 2024 May 24];38(7):3022-3027. Available from: https://doi.org/10.1093/molbev/msab120

Edgar RC. MUSCLE: multiple sequence alignment with high accuracy and high throughput. Nucleic Acids Res [Internet]. 2004 [cited 2024 May 24];32(5):1792-1797. Available from: http://dx.doi.org/10.1093/nar/gkh340.

Kimura M. A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. J Mol Evol [Internet]. 1980 [cited 2024 May 24];16(2):111-120. Available from: http://dx.doi.org/10.1007/bf01731581.

Saitou N, Nei M. The neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol Biol Evol [Internet]. 1987 [cited 2024 May 24];4(4):406-425. Available from: https://doi.org/10.1093/oxfordjournals.molbev.a040454

Imamura RYC, Alberghini LF, Oliveira MSC, Colombo EC. Isolamento e identificação de fungos filamentosos em slimes. J Health Sci Inst [Internet]. 2021 [cited 2024 May 24];39(1):13-7. Available from: https://repositorio.unip.br/journal-of-the-health-sciences-institute-revista-do-instituto-de-ciencias-da-saude/isolamento-e-identificacao-de-fungos-filamentosos-em-slimes/

Hardy A, Sabatier V, Rosello O, Salauze B, Barbut F, Vialle R. More than just teddy bears: Unconventional transmission agents in the operating room. Arch Pediatr [Internet]. 2018 [cited 2024 May 24];25(7):416-420. Available from: https://doi.org/10.1016/j.arcped.2018.08.003

Akedor U, Ita E, Ati B, Okon V, Adegbenro M. Public health implication of shared toys amongst children age 1-5 years attending crech and nursery schools within the cross river state region: a case study in Calabar Metropolis. Inter J Scien [Internet]. 2019 [cited 2024 May 24];8(1):37-42. Available from: https://doi.org/10.18483/ijSci.1842

Brasil. Ministério da Saúde. Agência Nacional de Vigilância Sanitária. Segurança do paciente em serviços de saúde: limpeza e desinfecção de superfícies. 1. ed. Brasília: Ministério da Saúde; 2010. Available from: http://antigo.anvisa.gov.br/documents/33852/271892/Manual+de+Limpeza+e+Desinfec%C3%A7%C3%A3o+de+Superf%C3%ADcies/1c9cda1e-da04-4221-9bd1-99def896b2b5

Gautam AK, Verma RK, Avasthi S, Sushma, Bohra Y, Devadatha B, Niranjan M, Suwannarach N. Current Insight into Traditional and Modern Methods in Fungal Diversity Estimates. J Fungi (Basel) [Internet]. 2022 [cited 2024 May 24];8(3):226-36. Available from: https://doi.org/10.3390/jof8030226

Batista CSB, Costa LV, Mantovani DP. Aspergilose: uma análise dos riscos de sua não notificação em ambientes hospitalares. Rev. Transformar [Internet]. 2020 [cited 2024 May 24];14(1):1-12. Available from: http://www.fsj.edu.br/transformar/index.php/transformar/article/view/289/203

Savín-Molina J, Hernández-Montiel LG, Ceiro-Catasú W, Ávila-Quezada GD, Palacios-Espinosa A, Ruiz-Espinoza FH, Romero-Bastidas M. Caracterización morfológica y potencial de biocontrol de especies de Trichoderma aisladas de suelos del semiárido. Rev. mex. fitopatol [Internet]. 2021 [cited 2024 May 24];39(3):435-451. Available from: https://doi.org/10.18781/r.mex.fit.2106-7

S Sautour M, Chrétien ML, Valot S, Lafon I, Basmaciyan L, Legouge C, et al. First case of proven invasive pulmonary infection due to Trichoderma longibrachiatum in a neutropenic patient with acute leukemia. J Mycol Med [Internet]. 2018 [cited 2024 May 24];28(4):659-662. Available from: https://doi.org/10.1016/j.mycmed.2018.10.001

Deberaldini MG, Santos JL. Infecções fúngicas invasivas: aspectos gerais e tratamento. Ulakes J Med. [Internet]. 2021 [cited 2024 May 24];1(3):209-221. Available from: http://revistas.unilago.edu.br/index.php/ulakes

Gustafson C, Koslosky M, Leslie J, Walczak C. Antifungal and Oral Anticancer Therapy Drug Interactions. Current Fungal Infection Reports [Internet]. 2020 [cited 2024 May 24];14(2020):130-140. Available from: https://doi.org/10.1007/s12281-020-00386-3

Denardi LB. Aspergillus spp.: Suscetibilidade aos antifúngicos isolados e em associação por diferentes metodologias e detecção de mecanismos de resistência a azólicos. [Tese]. Seropédica: Universidade Federal de Santa Maria; 2018.

Ibfelt T, Engelund EH, Schultz AC, Andersen LP. Effect of cleaning and disinfection of toys on infectious diseases and micro-organisms in daycare nurseries. J Hosp Infect [Internet]. 2015 [cited 2024 May 24]; 89(2):109-15. Available from: https://doi.org/10.1016/j.jhin.2014.10.007

Jimenez M. Disinfection alternatives for contact surfaces and toys at child care centers. Inter J Envir Health Res [Internet]. 2009 [cited 2024 May 24]; 20(6):387-94. Available from: https://doi.org/10.1080/09603123.2010.491851

Merriman E, Corwin P, Ikram R. Toys are a potential source of cross-infection in general practitioners' waiting rooms. Br J Gen Pract [Internet]. 2002 [cited 2024 May 24];52(475):138-40. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1314220/

Published

2024-07-27

How to Cite

Magalhães, B. S. ., Almeida, T. T. de ., Marques, L. M. A. ., Castro, L. E. L. de ., Roel, A. R. ., Oliveira, C. E. de ., … Marques, F. R. B. . (2024). DETECTION OF FUNGI IN FABRIC TOYS FOR IMMUNOCOMPROMISED CHILDREN. Journal of Infection Prevention and Health, 10(1). https://doi.org/10.26694/repis.v10i1.5701

Similar Articles

1 2 3 > >> 

You may also start an advanced similarity search for this article.