Perfil clínico- epidemiológico de pacientes com dengue com sinais de alarme e dengue grave em hospital universitário
DOI:
https://doi.org/10.26694/repis.v11i1.7099Palabras clave:
Dengue, Vírus da dengue, Epidemiologia clínica, MortalidadeResumen
Introdução: A dengue é uma arbovirose que possui crescente relevância em saúde pública, com espectro clínico variado que pode evoluir para formas graves. Objetivo: compreender o perfil clínico e epidemiológico de pacientes internados com diagnóstico de dengue com sinais de alerta e dengue grave em hospital referência de doenças tropicais da região Norte do Brasil, entre os anos de 2019 e 2024.
Delineamento: Estudo epidemiológico quantitativo, descritivo, documental, transversal e retrospectivo realizado no hospital universitário do Tocantins localizado no município de Araguaína-TO.
Resultados: Houve predominância de autodeclarados pardos, faixa etária de 10-19 anos e mulheres. O ano de 2021 apresentou o maior número de internações e o ano de 2022 o maior número de casos de dengue grave. As alterações clínicas vômitos persistentes, aumento progressivo do hematócrito e letargia e/ou irritabilidade possuem maior chance de evoluir para um quadro desfavorável da doença.
Implicações: O estudo apresenta aspectos relevantes que contribuem para formulação de estratégias que auxiliam no direcionamento de promoção de educação em saúde e no fortalecimento de políticas públicas voltadas ao controle da doença.
Citas
1. Yang J, Abdullah Al Mosabbir, Raheem E, Hu W, Mohammad Sorowar Hossain. Demographic characteristics, clinical symptoms, biochemical markers and probability of occurrence of severe dengue: A multicenter hospital-based study in Bangladesh. PLoS
Negl Trop Dis [Internet]. 2023 Mar 15 [cited 2025 Sep 11];17(3):e0011161–1. Available from: https://doi.org/10.1371/journal.pntd.0011161
2. Riaz M, Harun SNB, Mallhi TH, Khan YH, Butt MH, Husain A, et al. Evaluation of clinical and laboratory characteristics of dengue viral infection and risk factors of dengue hemorrhagic fever: a multi-center retrospective analysis. BMC Infect Dis [Internet]. 2024 May 17 [cited 2025 Sep 11];24(1):500. Available from: https://doi.org/10.1186/s12879-024-09384-z
3. Francelino E de O, Puccioni-Sohler M. Dengue and severe dengue with neurological complications: a challenge for prevention and control. Arq Neuropsiquiatr [Internet]. 2024 Dec [cited 2025 Sep 12];82(12):001–6. Available from:https://doi.org/10.1055/s-
0044-1792091
4. Cardoso FDP, Batista HL, Araújo BM, Nunes RM. Observações sobre a epidemiologia de dengue em Araguaína, Tocantins. Rev. Ciênc. Saúde [Internet]. 2012 Jan-Jun [cited 2025 Nov 19];14(1):05-14.
5. Souza UJB, Macedo YSM, Santos RN, Cardoso FDP, Galvão JD, Gabev EE, et al. Circulation of Dengue Virus Serotype 1 Genotype V and Dengue Virus Serotype 2 Genotype III in Tocantins State, Northern Brazil, 2021–2022. Viruses [Internet]. 2023 Oct 24 [cited 2025 Nov 17];15(11):2136. Available from: https://doi.org/10.3390/v15112136
6. Padhi BK, Khatib MN, Gaidhane S, Zahiruddin QS, Satapathy P, Rabaan AA, et al. Association of cardiovascular disease with severe dengue: A systematic review and meta-analysis. Curr Probl Cardiol [Internet]. 2024 Feb 1 [cited 2025 Sep 11];49(2):102346–6. Available from: https://doi.org/10.1016/j.cpcardiol.2023.102346
7. Brasil. Ministério da Saúde. Departamento de Doenças Transmissíveis. Dengue: diagnóstico e manejo clínico – adulto e criança. 6. ed. Brasília: Ministério da Saúde; 2024.
8. Kularatne SA, Dalugama C. Dengue infection: global importance, immunopathology and management. Clin Med [Internet]. 2022 Jan [cited 2025 Sep 12]; 22(1):9–13. Available from: https://doi.org/10.7861/clinmed.2021-0791
9. Nguyen Lam Vuong, Quyen H, Hanh T, Hue T, Le T, Phung Khanh Lam, et al. Dengue Viremia Kinetics and Effects on Platelet Count and Clinical Outcomes: An Analysis of 2340 Patients from Vietnam. eLife [Internet]. 2024 Jan 22 [cited 2025 Sep 12]; Available from: https://doi.org/10.7554/eLife.92606.3
10. von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP, et al. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: Guidelines for reporting observational studies. J Clin Epidemiol [Internet]. 2008 Apr [cited 2025 Nov 22];61(4):344-349. Available from: https://doi.org/10.1016/j.jclinepi.2007.11.008
11. Marty, Elizângela; Marty, Roseli Mari. Hematologia laboratorial. 1ª ed. São Paulo: Érica; 2014.
12. Anh D.D., The N.T., My T.N., Linh L.T.K., Hoan N.X., Kremsner P.G., et al. Epidemiology and genotype dynamics of dengue in hospitalized patients in Northern Vietnam between 2020 and 2022. Open Forum Infect. Dis. [Internet]. 2024 Dec 24 [cited 2025 Nov 17];12(1):ofae753. Available from: https://doi.org/10.1093/ofid/ofae753
13. Liu LT, Huang SY, Lin CH, Chen CH, Tsai CY, Lin PC, et al. The epidemiology and identification of risk factors associated with severe dengue during the 2023 dengue outbreak in Kaohsiung City, Taiwan. Travel Med Infect Dis [Internet]. 2025 Apr 10 [cited 2025 Sep 12]; 65:102852. Available from:https://doi.org/10.1016/j.tmaid.2025.102852
14. Silva TR da, Costa AKAN, Alves KAN, Santos AN, Cota M de F. Tendência temporal e distribuição espacial da dengue no Brasil. Cogitare enferm [Internet]. 2022 Nov 18[cited 2025 Sep 12]; 27(27):1–10. Available from: https://doi.org/10.5380/ce.v27i0.84000
15. Santos M,Boschiero MN, Augusto F. Dengue outbreaks in Brazil and Latin America: the new and continuing challenges. Int J Infect Dis [Internet]. 2024 Jul 1[cited 2025 Sep 12]; 147:107192–2. Available from: https://doi.org/10.1016/j.ijid.2024.107192
16. Kayesh MEH, Khalil I, Kohara M, Tsukiyama-Kohara K. Increasing dengue burden and severe dengue risk in Bangladesh: an Overview. Trop Med Infect Dis [Internet]. 2023 Jan 3[cited 2025 Sep 12]; 8(1):32. Available from: https://doi.org/10.3390/tropicalmed8010032
17. Che Isa Z, Lim JA,Mohamed Ain A, Othman FA, Kueh YC,Tew MM, et al. Clinical profiles and predictors of survival in severe dengue cases. Singapore Med J [Internet]. 2023 Nov 3[cited 2025 Sep 12]; Available from: https://doi.org/10.4103/singaporemedj.SMJ-2022-072
18. Yosef DK, Ismail AS, Awil BS, Hassan HA, Hassan MA. Epidemiology of dengue fever in Somaliland: clinical features, and serological patterns from a retrospective study. BMC Infect Dis. [Internet]. 2025 Feb 05 [cited 2025 Nov 19];25(1):179. Available from: https://doi.org/10.1186/s12879-025-10558-6
19. Brasil. Ministério da Saúde. Sistema de Informações Hospitalares do SUS (SIH/SUS) – Produção Hospitalar [Internet]. Brasília: Ministério da Saúde; 2025. [citado 2025 Out 18]. Available from: http://tabnet.datasus.gov.br/cgi/tabcgi.exe?sih/cnv/spgto.def
20. Jayarajah U, Lahiru M, de Zoysa I, Seneviratne SL. Dengue Infections and the Surgical Patient. Am J Trop Med Hyg. [Internet]. 2021 Jan 06 [cited 2025 Nov 19];104(1):52. Available from: https://doi.org/10.4269/ajtmh.20-0983
21. Flórez JES, Velasquez KM, Cardona LSG, Cardona ÁMS, Jaramillo BNR, Arboleda M. Dengue Severity Prediction in a Hyperendemic Region in Colombia. Viruses [Internet]. 2025 [Cited 2025 Sep 12]; 17(6):740. Available from: https://doi.org/10.3390/v17060740
22. Carras M, Maillard O, Cousty J, Gérardin P, Boukerrou M, Raffray L, et al. Associated risk factors of severe dengue in Reunion Island: A prospective cohort study. PLoS Negl Trop Dis [Internet]. 2023 Apr 1[cited 2024 Sep 12];17(4):e0011260. Available from: https://doi.org/10.1371/journal.pntd.0011260
23. Rodrigo C, Sigera C, Fernando D, Rajapakse S. Plasma leakage in dengue: a systematic review of prospective observational studies. BMC Infect Dis. [Internet]. 2021 Oct 20 [cited 2025 Nov 17];21(1):1082. Available from: https://doi.org/10.1186/s12879-021-06793-2
24. Tangpukdee N, Siripoon T, Lert-anamat K, Preechasuth K, Anekthanan A, Kanjana K, et al. Early-phase factors associated with pediatric severe dengue in the Thai-Myanmar cross-border region. BMC Public Health [Internet]. 2024 [cited 2024 Sep 12]; 24(1):1957. Available from: https://doi.org/10.1186/s12889-024-19492-9
25. Roy S.K, Ghosh B, Chakraborty A, Hazra S, Goswami BK, Bhattacharjee S, et al. Haematological parameters as predictors of severe dengue: a study from northern districts of West Bengal, India. J Vector Borne Dis. [Internet]. 2025 Apr–Jun [cited 2025 Nov 17];62(2):218–225. Available from: https://doi.org/10.4103/JVBD.JVBD_119_24
26. Prattay KMR, Sarkar MR, Shafiullah AZM, Islam MS, Raihan SZ, Sharmin N. A retrospective study on the socio-demographic factors and clinical parameters of dengue disease and their effects on the clinical course and recovery of the patients in a tertiary care hospital of Bangladesh. PLoS Negl Trop Dis. 2022 Apr [cited 2025 Aug 27];16(4):e0010297. Available from: https://doi.org/10.1371 journal.pntd.0010297
27. Gallego-Munuera M, Colomé-Hidalgo M. Dengue lethality and inequalities in the Region of the Americas between 2014 and 2023. Rev Panam Salud Publica. [Internet]. 2024 Dec 18 [cited 2025 Nov 19]; 48:e139. Available from: https://doi.org/10.26633/RPSP.2024.139
28. Silva ASA, Carvalho FL, Pinto GA, Saad LSR, Curado MO, Dombroski TCD, et al. Analysis of signs and symptoms in confirmed cases of severe dengue among children aged 0 to 10 years old. Einstein (Sao Paulo). 2024 Apr 29 [cited 2025 Sep 10]; 22:eAO0546. Available from: https://doi.org/10.31744/einstein_journal/2024ao0546
Publicado
Cómo citar
Número
Sección
Licencia
Derechos de autor 2025 Julia Leite Abreu, William Jacks Lopes Sousa, Melyssa Maria Barros Santos Carvalho, Wágnar Silva Morais Nascimento, Helcileia Dias Santos, Joaquim Guerra de Oliveira Neto, Silvia Minharro Barbosa Prado
Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
