Longitudinal analysis of morbidity and mortality due to septicemia and comparison with number of beds in Brazilian states

Authors

  • Ana Laura Pelissaro Pereira Universidade do Sul de Santa Catarina (UNISUL), Departamento de Medicina. Tubarão, Santa Cataria, Brasil
  • Beatriz Orlandi Rodrigues Universidade do Sul de Santa Catarina (UNISUL), Departamento de Medicina. Tubarão, Santa Cataria, Brasil
  • Kelser de Souza Kock Universidade do Sul de Santa Catarina (UNISUL), Departamento de Medicina. Tubarão, Santa Cataria, Brasil

DOI:

https://doi.org/10.26694/repis.v10i1.5349

Keywords:

Sepsis, Morbidity, Mortality, Hospital Bed Capacity

Abstract

Introduction: Sepsis is a serious organic dysfunction triggered by the body's unregulated response to infection, with globally increasing morbidity and mortality rates. In Brazil, challenges such as inequality in bed availability affect management. Aim: To analyze morbidity and mortality due to sepsis in 2012 and 2022 in Brazilian states, relating them to the number of hospital beds. Outlining: ecological time series study, with data collected from DATASUS. The dependent variables were morbidity and mortality and lethality due to septicemia, and the independent variables included time and number of beds.  Results: A significant increase in morbidity and mortality cases was observed in Brazil and in most Brazilian states. The average lethality was 45.09%, with extremes in Rio de Janeiro (58.2%) and Roraima (25.9%). Analysis by age range showed an increase with age and similarity between genders. Significant positive correlations were demonstrated between number of beds and morbidity and mortality and negative correlation with lethality. Implications: this study provides the basis for implementing measures that aim to improve the care and prevention of septicemia in Brazil, inferring that states with a greater number of hospital beds have better quality and access to care and, therefore, greater diagnostic and treatment capacity.

References

Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA [Internet]. 2016 [cited 2023 Nov 21];315(8):801–10. Available from: https://doi.org/10.1001/jama.2016.028

Srzić I, Adam VN, Pejak DT, Srzić I. Sepsis definition: What’s new in the Treatment Guidelines. Acta clinica croatica [internet]. 2022 [cited 2023 Nov 14];61(1): 67-72. Available from: https://doi.org/10.20471/acc.2022.61s1.11

Goldstein E, MacFadden DR, Karaca Z, Steiner CA, Viboud C, Lipsitch M. Antimicrobial resistance prevalence, rates of hospitalization with septicemia and rates of mortality with sepsis in adults in different US states. International Int J Antimicrob Agents [Internet]. 2019 [cited 2023 Nov 21];54(1):23–34. Available from: https://doi.org/10.1016/j.ijantimicag.2019.03.004

Leischmann C, Scherag A, Adhikari NKJ, Hartog CS, Tsaganos T, Schlattmann P, et al. Assessment of Global Incidence and Mortality of Hospital-treated Sepsis. Current Estimates and Limitations. Am J Respir Crit Care Med [Internet]. 2016 [cited 2023 Nov 12];193(3):259–72. Available from: https://doi.org/10.1164/rccm.201504-0781OC

Prescott HC, Angus DC. Enhancing Recovery From Sepsis: A Review. JAMA [Internet]. 2018 [cited 2023 Nov 13];319(1):62. Available from: https://doi.org/10.1001/jama.2017.17687

Neira RAQ, Hamacher S, Japiassú AM. Epidemiology of sepsis in Brazil: Incidence, lethality, costs, and other indicators for Brazilian Unified Health System hospitalizations from 2006 to 2015. Plos One [Internet]. 2018 [cited 2023 Nov 19];13(4):1-15. Available from: https://doi.org/10.1371/journal.pone.0195873

Instituto Brasileiro de Geografia e Estatística (IBGE). Brasil em síntese: proporção da população por grandes grupos de idade. Rio de Janeiro: IBGE; 2022. Available from: https://brasilemsintese.ibge.gov.br/populacao/distribuicao-da-populacao-por-grandes-grupos-de-idade

Conde KAP, Silva E, Silva CO, Ferreira E, Freitas FGR, Castro I, et al. Differences in Sepsis Treatment and Outcomes between Public and Private Hospitals in Brazil: A Multicenter Observational Study. PLoS ONE [Internet]. 2013 [cited 2023 Nov 21];8(6):1-11. Available from: https://doi.org/10.1371/journal.pone.0064790

Fernández-Sarmiento J, Carcillo JA, Salinas CA, Humberto E, López PH, Jagua-Gualdrón A. Effect of a Sepsis Educational Intervention on Hospital Stay. Pediatr Crit Care Med [Internet]. 2018 [cited 2023 Nov 21];19(6):1-8. Available from: https://doi.org/10.1097/PCC.0000000000001536

Paiva P, Antunes R, Vercesi M. Inequalities in the provision of hospital care in the Covid-19 pandemic in Brazil: an integrative review. Saúde Debate [Internet]. 2022 [cited 2023 Nov 11];46(1):322–37. Available from: https://doi.org/10.1590/0103-11042022E122I

Brasil. Ministério da Saúde. 71% dos brasileiros têm os serviços públicos de saúde como referência. Brasília: Biblioteca Virtual em Saúde MS; 2023. Available from: https://bvsms.saude.gov.br/71-dos-brasileiros-tem-os-servicos-publicos-de-saude-como-referencia/

Instituto Brasileiro de Geografia e Estatística (IBGE). IBGE divulga estimativa da população dos municípios para 2020. Rio de Janeiro: IBGE; 2020. Available from: https://agenciadenoticias.ibge.gov.br/agencia-sala-de-imprensa/2013-agencia-de-noticias/releases/28668-ibge-divulga-estimativa-da-populacao-dos-municipios-para-2020

Matos JC, Ferreira LF, Borges RS. A escassez de leitos hospitalares no contexto da judicialização da saúde: um estudo de caso. Rev Eletr grup estud EJEF [Internet]. 2021 [cited 2023 Nov 21]:1-31. Available from: https://ejef.tjmg.jus.br/wp-content/uploads/2022/06/A-escassez-de-leitos-hospitalares-no-contexto-da-judicializacao-da-saude_um-estudo-de-caso.pdf

Lima FBMP, Clemente HA, Soares AA, Cunha GLC, Faustino TN, Da Silva JA. Strategies for the bed management process in hospitals: An integrative review. Saúde Coletiva (Barueri) [Internet]. 2023 [cited 2023 Nov 21];13(84):12362–72. Available from: https://doi.org/10.36489/saudecoletiva.2023v13i84p12362-12383

Associação de Medicina Intensiva Brasileira (AMIB). AMIB apresenta dados atualizados sobre leitos de UTI no Brasil. São Paulo: AMIB; 2020. Available from:: https://www.epsjv.fiocruz.br/sites/default/files/files/dados_uti_amib(1).pdf

Brasil. Ministério da Saúde. Informações de Saúde (TABNET) – DATASUS. Brasília: Ministério da Saúde; 2013. Available from: https://datasus.saude.gov.br/informacoes-de-saude-tabnet/

Rhee C, Klompas M. Sepsis trends: increasing incidence and decreasing mortality, or changing denominator?. J Thorac Dis [Internet]. 2020 [cited 2023 Nov 21];12(Suppl 1):S89-S100. Available from: https://doi.org/10.21037/jtd.2019.12.51

Fleischmann-Struzek C, Mellhammar L, Rose N, Cassini A, Rudd KE, Schlattmann P, et al. Incidence and mortality of hospital- and ICU-treated sepsis: results from an updated and expanded systematic review and meta-analysis. Intensive Care Med [Internet]. 2020 [cited 2023 Nov 20] ;46(8):1552-1562. Available from: https://doi.org/10.1007/s00134-020-06151-x

Almeida NRC, Pontes GF, Jacob FL, Depra JVS, Porto JPP, Lima FR, et al. Analysis of mortality trends due to sepsis in Brazil and by regions from 2010 to 2019. Rev Saude Publica [Internet]. 2022 [cited 2023 Nov 11];56(25):1-13. Available from: https://doi.org/10.11606/s1518- 8787.2022056003789

Bauer M, Gerlach H, Vogelmann T, Preissing F, Stiefel J, Adam D. Mortality in sepsis and septic shock in Europe, North America and Australia between 2009 and 2019— results from a systematic review and meta-analysis. Crit Care [Internet]. 2020 [cited 2023 Nov 21];24(1):239. Available from: https://doi.org/10.1186/s13054-020-02950-2

Evans L, Rhodes A, Alhazzani W, Antonelli M, Coopersmith CM, French C, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Intensive Care Med. [Internet] . 2021 [cited 2023 Nov 21]; 49(11):1-71. Available from: https://doi.org/10.1007/s00134-021-06506-y

Instituto do Desenvolvimento Agrário do Ceará (IDACE). Estudo mostra o mapa da desigualdade da distribuição de terras no Brasil. Fortaleza: IDACE; 2020. Available from: https://www.idace.ce.gov.br/2020/05/13/estudo-mostra-o-mapa-da-desigualdade-da-distribuicao-de-terras-no-brasil/

Bezerra CJ, Trovão M. A Pandemia da Covid-19 e a Desigualdade de Renda no Brasil: Um Olhar Macrorregional para a Proteção Social e os Auxílios Emergenciais. Natal: UFRN; 2020. Available from: https://ccsa.ufrn.br/portal/wp-content/uploads/2020/05/TROV%C3%83O-2020-PANDEMIA-E-DESIGUALDADE.pdf

Eriksson CO, Stoner RC, Eden KB, Newgard CD, Guise JM. The Association Between Hospital Capacity Strain and Inpatient Outcomes in Highly Developed Countries: A Systematic Review. J Gen Intern Med [Internet]. 2017 [cited 2023 Nov 20];32(6):686-696. Available from: https://doi.org/10.1007/s11606-016-3936-3

Dantes RB, Kaur H, Bouwkamp BA, Haass KA, Patel P, Dudeck MA, et al. Sepsis Program Activities in Acute Care Hospitals - National Healthcare Safety Network, United States, 2022. MMWR Morb Mortal Wkly Rep [Internet]. 2023 [cited 2023 Nov 16];72(34):907-911. Available from: https://doi.org/10.15585/mmwr.mm7234a2

Atalay K, Edwards RW, Georgiakakis F. Mortality inequality, spatial differences and health care access. Health Econ [Internet]. 2023 [cited 2023 Nov 20];32:2632–54. Available from: https://doi.org/10.1002/hec.4746

Ravaghi H, Alidoost S, Mannion R, Bélorgeot VD. Models and methods for determining the optimal number of beds in hospitals and regions: a systematic scoping review. BMC Health Serv Res [Internet] 2020 [cited 2023 Nov 13];20(1):1-13. Available from: https://doi.org/10.1186/s12913-020-5023-z

Coube M, Nikoloski Z, Mrejen M, Mossialos E. Persistent inequalities in health care services utilisation in Brazil (1998–2019). Int J Equity Health [Internet]. 2023 [cited 2023 Nov 14];22(1):1-15. Available from: https://doi.org/10.1186/s12939-023-01828-3

Instituto Brasileiro de Geografia e Estatística (IBGE). De 2010 a 2022, população brasileira cresce 6,5% e chega a 203,1 milhões. Rio de Janeiro: IBGE; 2023. Available from: https://agenciadenoticias.ibge.gov.br/agencia-noticias/2012-agencia-de-noticias/noticias/37237-de-2010-a-2022-populacao-brasileira-cresce-6-5-e-chega-a-203-1-milhoes

Published

2024-07-27

How to Cite

Pereira, A. L. P., Rodrigues, B. O. ., & Kock, K. de S. (2024). Longitudinal analysis of morbidity and mortality due to septicemia and comparison with number of beds in Brazilian states. Journal of Infection Prevention and Health, 10(1). https://doi.org/10.26694/repis.v10i1.5349

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